Common side effects of marrow donation include:. Some donors said the experience was more painful than they expected; others said it was less painful. Some donors describe the pain as similar to achy hip bones or falling on their buttocks. Others say it feels more like a strained muscle in the back. The ache may last a few days to several weeks. We want to assure donor safety, but no medical procedure is risk-free. The majority of donors from the Be The Match Registry feel completely recovered within a few weeks.
A small percentage 2. The risk of side effects of anesthesia during marrow donation is similar to that during other surgical procedures. Serious side effects of anesthesia are rare. Common side effects of general anesthesia include sore throat caused by the breathing tube or mild nausea and vomiting.
Common side effects of regional anesthesia are a decrease in blood pressure and a headache after the procedure. We take all the necessary precautions to ensure the safety and well-being of the donor. To learn more, see Donor safety and support. The amount of marrow donated will not weaken your own body or immune system. The average amount of marrow and blood donated is about one quart, less if the patient is a baby or child.
This is only a fraction of your total marrow. Most donors are back to their usual routine in a few days, and your marrow naturally replaces itself within four to six weeks. The donation will be scheduled at a hospital that works with the NMDP. Peripheral blood stem cell PBSC donation is a way to collect blood-forming cells for transplantation. The same blood-forming cells sometimes called blood stem cells that can be donated from the bone marrow are also found in the circulating peripheral blood.
Before donation, a donor takes injections of a drug called filgrastim to move more blood-forming cells out of the marrow and into the bloodstream. Then the donor's blood is removed through a needle in one arm and passed through a machine that separates out the blood-forming cells.
This process is similar to donating plasma. The study is investigating whether blood-forming cells from the peripheral blood can be used as effectively as blood-forming cells from bone marrow for unrelated donor transplantation. A clinical research study has a written set of instructions for how a donation will be carried out. It is an important scientific way to evaluate the effectiveness of the procedure for both donors and recipients.
Receiving filgrastim injections: To move more blood-forming cells from your bone marrow to your bloodstream, you will receive filgrastim, a drug given by injection each day for five days before the donation.
The first injection will be given at a donor center or medical clinic. You may receive injections on days two, three and four at your place of work, your home, at a donor center or at a medical clinic.
On the fifth day, you will receive your final dose of filgrastim, and then donate your blood cells at the donor center or hospital outpatient unit. Donating the cells: PBSC donation is done through a process called apheresis, which is similar to donating plasma. During apheresis, a needle will be placed into each of your arms.
Blood will be removed from a vein in one arm and passed through tubing into a blood cell separator machine. The machine collects blood-forming cells, platelets and some white blood cells. This process is called apheresis. It typically takes up to two hours and is done as an outpatient procedure.
You'll typically undergo two to four apheresis sessions, depending on how many blood stem cells are needed. Recovery times vary depending on the individual and type of donation. But most blood stem cell donors are able to return to their usual activities within a few days to a week after donation. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. This content does not have an English version. This content does not have an Arabic version.
Overview If you are planning to donate stem cells, you have agreed to allow doctors to draw bone marrow stem cells from either your blood or bone marrow for transplantation.
Request an Appointment at Mayo Clinic. Share on: Facebook Twitter. Show references Stem cell transplant for cancer. American Cancer Society. Accessed May 7, Blood-forming stem cell transplants.
National Cancer Institute. FAQs about joining. National Marrow Donor Program. Micromedex 2. HLA matching. Myths and facts about bone marrow donation. The result of this test shows how good the HLA match is between you and the person who needs the cells. A brother or sister is most likely to be a match.
There is a 1 in 4 chance of your cells matching. This is called a matched related donor MRD transplant. Anyone else in the family is unlikely to match. This can be very frustrating for relatives who are keen to help. This is called a haploidentical transplant. It's sometimes possible to get a match from someone outside of the family. This is called a matched unrelated donor. To find a matched unrelated donor, it's usually necessary to search large numbers of people whose tissue type has been tested.
So doctors search national and international registers to try to find a match for your relative. Even if you can't donate to your relative, you might be able to become a donor for someone else. You can do this by contacting one of the UK registers. There are different donor registers in the UK. So doctors search national and international registers to try to find a match for your relative. Even if you can't donate to your relative, you might be able to become a donor for someone else.
You can do this by contacting one of the UK registers. There are different donor registers in the UK. These work with each other and with international registers to match donors with people who need stem cells. This helps doctors find donors for their patients as quickly as possible from anywhere in the world. Each registry has specific health criteria and list medical conditions that might prevent you from donating.
Check their website for this information. Once registered, the organisation will contact you if you are a match for someone who needs stem cells or bone marrow.
To register with the BBMR, you must be a blood donor. BBMR would like to register those groups they are particularly short of on their register.
This includes men between the ages of 17 and And women aged between 17 and 40 who are from Black, Asian, and minority ethnicities and mixed ethnicity backgrounds. You must be aged between 16 and 30 to register with Anthony Nolan.
You have a cheek swab to test for tissue typing.
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